What we know so far about the rollout of the new Oxford AstraZeneca Covid vaccine

Researchers at Oxford University whose coronavirus vaccine, developed in association with AstraZeneca, has now been approved for use in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA).

The Covid-19 vaccine developed by the University of Oxford and AstraZeneca has been approved for use in the UK.

Peterborough City Hospital was one of the first 60 vaccine sites in the country and it is understood that the new vaccine will be rolled out initially from those hubs to each of the priority categories in turn.

With the Pfizer/BioNTech jab already being administered to the most vulnerable, what does this new development mean?

A scientist at work in the manufacturing laboratory where a vaccine against Covid-19 has been produced at the Oxford Vaccine Group's facility at the Churchill Hospital in Oxford. The vaccine, which has been described as a "game changer", has now been approved for use in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA).

– What’s in the pipeline for the UK?

The Government has secured 100 million doses of the Oxford vaccine.

The initial doses of the Oxford jab are due to be dispatched from Germany, with a large proportion then manufactured in the UK.

Like the Pfizer/BioNTech vaccine, people will need two doses.

There will be four million doses available post authorisation and tens of millions of doses in the first quarter of next year.

A specific schedule is difficult to establish as batches need to be quality approved by the Medicines and Healthcare products Regulatory Agency (MHRA).

– How will a vaccine be rolled out?

The Oxford vaccine can be stored at fridge temperature for at least six months so it is hoped the logistics of administering it will be easier.

Health Secretary Matt Hancock said the approval was “fantastic news” and confirmed that the roll out would begin on January 4.

AstraZeneca said was it is building up a manufacturing capacity of up to three billion doses worldwide next year, and aims to supply the UK with millions of doses in the first quarter in 2021.

People will be given a first dose of the jab, with a second dose up to 12 weeks later.

– Now there are more vaccines, does this mean a wider range of people can be vaccinated?

All of the people at the top of the priority list created by the Joint Committee on Vaccination and Immunisation (JCVI) have not yet been vaccinated.

Therefore vaccinators will continue to work their way through the list.

It is hoped more people in care homes will be reached with the rollout of the Oxford AstraZeneca vaccine.

The JCVI’s guidance says the order of priority should be:

1. Older adults in a care home and care home workers

2. All those who are 80 years of age and over and health and social care workers

3. All those who are 75 years of age and over

4. All those who are 70 years of age and over and clinically extremely vulnerable individuals, excluding pregnant women and those under 18 years of age

5. All those who are 65 years of age and over

6. Individuals aged 16 to 64 years with underlying health conditions

7. All those aged 60 and over

8. All those aged 55 and over

9. All those aged 50 and over

– Don’t vaccines take a long time to produce?

In the past it has taken years, sometimes decades, to produce a vaccine. Traditionally, vaccine development includes various processes, including design and development stages followed by clinical trials – which in themselves need approval before they even begin.

But in the trials for a Covid-19 vaccine, things look slightly different. A process which usually takes years has been condensed to months.

While the early design and development stages look similar, the clinical trial phases overlap, instead of taking place sequentially.

And pharmaceutical firms have begun manufacturing before final approval has been granted – taking on the risk that they may be forced to scrap their work.

The new way of working means that regulators around the world can start to look at scientific data earlier than they traditionally would do.

- Is the Oxford vaccine being manufactured in the UK?

While there are some doses coming from Europe in the very first instance, the majority will be provided from the UK supply chain.

– Aren’t there other vaccines?

Yes. As well as the Pfizer vaccine which has an efficacy of 95%, a number of other jabs the UK has secured doses of.

Oxford data indicates the vaccine has 62.1% efficacy when one full dose is given followed by another full dose, but when people were given a half dose followed by a full dose at least a month later, its efficacy rose to 90%.

The combined analysis from both dosing regimes resulted in an average efficacy of 70.4%.

Final results from the trials of Moderna’s vaccine suggest it has 94.1% efficacy, and 100% efficacy against severe Covid-19.

– Which jab is best?

The early contenders all have high efficacy rates, but researchers say it is difficult to make direct comparisons because it is not yet known exactly what everyone is measuring in the trials.

– How many doses has the UK secured?

The UK has secured access to 100 million doses of the AstraZeneca/Oxford University vaccine, which is almost enough for most of the population.

It also belatedly struck a deal for seven million doses of the jab on offer from Moderna in the US.

The deals cover four different classes: adenoviral vaccines, mRNA vaccines, inactivated whole virus vaccines and protein adjuvant vaccines.

The UK has secured access to:

– 100 million doses of the Oxford vaccine

– 60 million doses of the Novavax vaccine

– Some 30 million doses from Janssen

– 40 million doses of the Pfizer/BioNTech vaccine – the first agreement the firms signed with any government

– 60 million doses of a vaccine being developed by Valneva

– 60 million doses of protein adjuvant vaccine from GlaxoSmithKline (GSK) and Sanofi Pasteur

– Seven million doses of the jab on offer from Moderna in the US.

– What do they cost?

Pfizer/BioNTech is making its vaccine available not-for-profit.

According to reports, the Moderna vaccine could cost about 38 dollars (£28) per dose and the Pfizer candidate could cost around 20 dollars (£15).

Researchers suggest the Oxford vaccine could be relatively cheap to produce, with some reports indicating it could be about £3 per dose.

AstraZeneca said it will not sell it for a profit, so it can be available to all countries.

However, the details of the deals made by the UK Government have not been made public.

– How do we know the vaccines are safe?

Researchers reported their trials do not suggest any significant safety concerns.

– Will people get a choice about which vaccine they are given?

As things stand the vaccines will be rolled out as and when they become available.

No announcement has been made on whether one might be given priority over another as they become ready on a mass scale.

People are not expected to be able to choose which jab they want to receive.