Hinchingbrooke Cup holders Peterborough Northern Star will begin their defence of the trophy at home to Stewart & Lloyds.
Star finished seventh in the United Counties League Premier Division last season while Stewart & Lloyds finished bottom in Division One.
In the UCL Knockout Cup, Star have also been drawn at home in the first round. They face Huntingdon Town.
Peterborough Sports, Holbeach, Yaxley and Deeping are all involved in preliminary round ties.
League Knockout Cup
Boston Town v Stewarts & Lloyds; Holbeach v Bugbrooke; Leicester Nirvana v Newport Pagnell; Raunds v Yaxley; Kirby Muxloe v Sleaford; Peterborough Sports v Burton PW; Rothwell Corinthians v Oakham; Wellingborough v Long Buckby; Desborough v Deeping; Oadby v Irchester.
Holbeach/Bugbrooke v Blackstones; Desborough/Deeping v Cogenhoe; Peterborough Northern Star v Huntingdon; AFC Kempston v Northampton Spencer; ON Chenecks v Wisbech; Harrowby v Whitworth; Bourne v Rothwell Corinthians/Oakham; Harborough v Olney; Kirby Muxloe/Sleaford v Woodford; Lutterworth Athletic v Oadby/Irchester; Boston Town/Stewarts & Lloyds v Potton; Rushden & Higham v Buckingham; Thrapston v Peterborough Sports/Burton PW; St Neots Saints v Eynesbury; Wellingborough/Long Buckby v Sileby; Raunds/Yaxley v Leicester Nirvana/Newport Pagnell.
Reserve Knockout Cup
Irchester v Rushden & Higham; Bourne v Huntingdon; Bugbrooke v Thrapston; Rothwell Corinthians v Harborough; Peterborough Northern Star v Whitworth; Cogenhoe v ON Chenecks; Potton v Olney; Northampton Spencer v Raunds.
Bourne/Huntingdon v Irchester/Rushden & Higham; Potton/Olney v Northampton Spencer v Raunds; Bugbrooke/Thrapston v Cogenhoe/ON Chenecks; Peterborough Northern Star/Whitworth v Rothwell Corinthians/Harborough.
Preliminary Round (by 15/10)
Bourne v Potton.
First Round (by 31/10)
Ooakham v Netherton; St Neots Saints v Peterborough Sports; AFC Kempston v Deeping; Thrapston v Yaxley; Bourne/Potton v Godmanchester; Huntingdon v Wisbech St Mary; Peterborough Northern Star v Stewart & Lloyds; Stotfold v Eynesbury.
Bourne Reserves v Langtoft/Glinton & Northborough.