Pupils at St John Fisher Catholic High School passed 99 per cent of their exams, with 80 per cent of students passing three or more subjects.
Forty four per cent of grades awarded were A*-B.
Among the high achieving students was head boy Hassan Nawaz whose A*, A and B grades secured his place to read medicine at University College London.
In five subjects – RE, art, biology, ICT and music – every student achieved a grade C or above.
In ICT every student achieved a grade B or above, and in music every student achieved at least an A.
Headteacher Sean Hayes said: “We are delighted with these excellent results which reflect the hard work of the students and their teachers.
“This was a larger group of students than previously, taking a larger range of subjects, so I am pleased that they have achieved well across the board.
“My congratulations to them all and best wishes for whatever they have chosen to do next.”