The demolition works at the former district hospital site took a step forward on Monday as bulldozers began taking down the main building for the first time.
The landmark moment comes just a month after developers threatened to halt demolition due to money difficulties.
And today city councillors and other representatives will be on the site as building work starts on the new 630-place West Town Primary Academy which is moving into the location.
Demolition at the site in Thorpe Road, which was bought by Lands Improvement Holdings (LIH) for £7.75 million, began in December but had until now avoided the main building.
The administrative core of the Memorial Hospital, built in homage to the fallen of the Great War, was meant to remain untouched following an outline planning application agreed by councillors last July.
But a detailed application passed in August agreed that it could be largely demolished and re-built.
The new school building for West Town will open in 2016. The council is providing £500,000 of funding for the school and the government is providing £6 million.