Motorists are facing long delays on the Fletton Parkway this lunchtime.
Traffic is very heavy by the Hampton roundabout, with the emergency services seen in the area.
A police spokesman said an HGV has rolled over at Kingston Park, Flaxley Road, near Amazon, with officers called shortly after 1pm.
The fire service was being sent to the scene.
The spokesman said there were no injuries.
The road has been partially closed.