A dog and seven puppies were stolen from St Johns Fen End, near Wisbech.
The thieves broke into a kennel at an address on Trinity Road between 8pm on Tuesday night and 2am the next morning.
A Cavalier King Charles Spaniel, black in colour with white marks on her face, and her four one-week old puppies were taken. The puppies, three male and one female, are black and tan in colour.
Three female Pug puppies were also stolen; they are 10 weeks old and fawn in colour with black faces.
The dogs are worth several thousand pounds and police would like to hear from anyone who may have witnessed the incident or has information concerning their whereabouts.
Anyone with information should contact PC Adam Oliver at King’s Lynn Police Station on 101 or call Crimestoppers anonymously on 0800 555 111.